Analytical Data
-
基因名
TTLL2
- Application
-
别名
TTLL2; C6orf104; Probable tubulin polyglutamylase TTLL2; EC 6.-.-.-; Testis-specific Protein NYD-TSPG; Tubulin--tyrosine ligase-like Protein 2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9BWV7
-
表达区间
1-592 aa
-
氨基酸序列
MRGRDLCSST QSQALGSLRT TTPAFTLNIP SEANHTEQPP AGLGARLQEA GVSIPPRRGR PTPTLEKKKK PHLMAEDEPS GALLKPLVFR VDETTPAVVQ SVLLERGWNK FDKQEQNAED WNLYWRTSSF RMTEHNSVKP WQQLNHHPGT TKLTRKDCLA KHLKHMRRMY GTSLYQFIPL TFVMPNDYTK FVAEYFQERQ MLGTKHSYWI CKPAELSRGR GILIFSDFKD FIFDDMYIVQ KYISNPLLIG RYKCDLRIYV CVTGFKPLTI YVYQEGLVRF ATEKFDLSNL QNNYAHLTNS SINKSGASYE KIKEVIGHGC KWTLSRFFSY LRSWDVDDLL LWKKIHRMVI LTILAIAPSV PFAANCFELF GFDILIDDNL KPWLLEVNYS PALTLDCSTD VLVKRKLVHD IIDLIYLNGL RNEGREASNA THGNSNIDAA KSDRGGLDAP DCLPYDSLSF TSRMYNEDDS VVEKAVSVRP EAAPASQLEG EMSGQDFHLS TREMPQSKPK LRSRHTPHKT LMPYASLFQS HSCKTKTSPC VLSDRGKAPD PQAGNFVLVF PFNEATLGAS RNGLNVKRII QELQKLMNKQ HS
-
分子量
67.3 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TTLL2 (Tubulin Tyrosine Ligase Like 2) is an important enzyme that plays a crucial role in the post-translational modification of tubulin, specifically in the addition of tyrosine residues to the C-terminus of α-tubulin. This modification is essential for microtubule stability and function, impacting various cellular processes such as cell division, intracellular transport, and signaling pathways. Research on TTLL2 has gained significance due to its potential implications in various diseases, including cancer and neurodegenerative disorders. Aberrant regulation of microtubule dynamics has been linked to tumor progression and metastasis, making TTLL2 a candidate for targeted therapeutic strategies. Additionally, studies suggest that TTLL2 may play a role in neuronal function and development, as alterations in its activity could influence neuronal structure and function. Understanding the biochemical properties, expression patterns, and regulatory mechanisms of TTLL2 is critical for elucidating its functional roles in health and disease. Consequently, the production of recombinant TTLL2 proteins has become an important focus of research, enabling detailed investigations into its enzymatic activity, substrate specificity, and interactions with other cellular components. By characterizing TTLL2 recombinantly, researchers aim to uncover its precise role in microtubule regulation and explore the potential of modulating its activity as a novel therapeutic approach for conditions characterized by microtubule dysregulation.
