Analytical Data
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基因名
TTLL13
- Application
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别名
TTLL13P; TTLL13; Tubulin polyglutamylase TTLL13P; EC 6.-.-.-; Tubulin tyrosine ligase-like family member 13 pseudogene; Tubulin--tyrosine ligase-like Protein 13
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A6NNM8
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表达区间
1-459 aa
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氨基酸序列
MEPSTCRTMESEEDYVEEKESEKCVKEGVTNPSNSSQQALLKADYKALKNGVPSPIMATKIPKKVIAPVDTGDLEAGRRKRRRKRRSLAINLTNCKYESVRRAAQMCGLKEVGEDEEWTLYWTDCAVSLERVMDMKRFQKINHFPGMTEICRKDLLARNLNRMYKLYPSEYNIFPRTWCLPADYGDFQSYGRQRKARTYICKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVLITSCDPLRIFTYEEGLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENFVRDGAVGSKRKLSTLNIWLQEHSYNPGELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLNGGTCACFEILGFDILLDHKLKPWLLEVNHSPSFTTDSCLDQEVKDALLCDAMTLVNLRGCDKRKVMEEDKRRVKERLFQCYRQPRESRCARCLACV
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分子量
50.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TTLL13, a member of the tubulin tyrosine ligase (TTL) family, has garnered significant interest in recent years due to its pivotal role in post-translational modifications of tubulin, which are critical for microtubule dynamics and cellular functions. As a key player in polyglutamylation, TTLL13 modifies the C-terminal region of tubulin, influencing processes such as neuronal development, cell division, and signal transduction. Dysregulation of polyglutamylation has been implicated in various diseases, including neurodegenerative disorders and cancer, making TTLL13 a potential therapeutic target. Research has focused on elucidating its enzymatic mechanisms, substrate specificity, and interaction with other cellular components. Furthermore, TTLL13's expression patterns in different tissues and its impact on cellular activities have opened new avenues for understanding its functional significance in health and disease. As studies advance, TTLL13 may pave the way for innovative strategies in regenerative medicine and targeted therapies, underscoring the importance of this enzyme in cellular homeostasis and pathology.
