Analytical Data
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Gene name
TTLL13
- Application
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Alternative Names
TTLL13P; TTLL13; Tubulin polyglutamylase TTLL13P; EC 6.-.-.-; Tubulin tyrosine ligase-like family member 13 pseudogene; Tubulin--tyrosine ligase-like Protein 13
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A6NNM8
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Expression Region
1-459 aa
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AA Sequence
MEPSTCRTMESEEDYVEEKESEKCVKEGVTNPSNSSQQALLKADYKALKNGVPSPIMATKIPKKVIAPVDTGDLEAGRRKRRRKRRSLAINLTNCKYESVRRAAQMCGLKEVGEDEEWTLYWTDCAVSLERVMDMKRFQKINHFPGMTEICRKDLLARNLNRMYKLYPSEYNIFPRTWCLPADYGDFQSYGRQRKARTYICKPDSGCQGRGIFITRNPREIKPGEHMICQQYISKPLLIDGFKFDMRVYVLITSCDPLRIFTYEEGLARFATTPYMEPSHNNLDNVCMHLTNYAINKHNENFVRDGAVGSKRKLSTLNIWLQEHSYNPGELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLNGGTCACFEILGFDILLDHKLKPWLLEVNHSPSFTTDSCLDQEVKDALLCDAMTLVNLRGCDKRKVMEEDKRRVKERLFQCYRQPRESRCARCLACV
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Molecular Weight
50.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TTLL13, a member of the tubulin tyrosine ligase (TTL) family, has garnered significant interest in recent years due to its pivotal role in post-translational modifications of tubulin, which are critical for microtubule dynamics and cellular functions. As a key player in polyglutamylation, TTLL13 modifies the C-terminal region of tubulin, influencing processes such as neuronal development, cell division, and signal transduction. Dysregulation of polyglutamylation has been implicated in various diseases, including neurodegenerative disorders and cancer, making TTLL13 a potential therapeutic target. Research has focused on elucidating its enzymatic mechanisms, substrate specificity, and interaction with other cellular components. Furthermore, TTLL13's expression patterns in different tissues and its impact on cellular activities have opened new avenues for understanding its functional significance in health and disease. As studies advance, TTLL13 may pave the way for innovative strategies in regenerative medicine and targeted therapies, underscoring the importance of this enzyme in cellular homeostasis and pathology.
