Analytical Data
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基因名
TRIM41
- Application
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别名
E3 ubiquitin-Protein ligase TRIM41; MGC1127; MGC31991; RINCK; RING finger Protein that interacts with C kinase; RING finger-interacting Protein with C kinase; TRI41_HUMAN; Trim41; Tripartite motif containing 41; Tripartite motif-containing Protein 41
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WV44
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表达区间
1-630 aa
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氨基酸序列
MAAVAMTPNP VQTLQEEAVC AICLDYFTDP VSIGCGHNFC RVCVTQLWGG EDEEDRDELD REEEEEDGEE EEVEAVGAGA GWDTPMRDED YEGDMEEEVE EEEEGVFWTS GMSRSSWDNM DYVWEEEDEE EDLDYYLGDM EEEDLRGEDE EDEEEVLEEV EEEDLDPVTP LPPPPAPRRC FTCPQCRKSF PRRSFRPNLQ LANMVQVIRQ MHPTPGRGSR VTDQGICPKH QEALKLFCEV DEEAICVVCR ESRSHKQHSV VPLEEVVQEY KAKLQGHVEP LRKHLEAVQK MKAKEERRVT ELKSQMKSEL AAVASEFGRL TRFLAEEQAG LERRLREMHE AQLGRAGAAA SRLAEQAAQL SRLLAEAQER SQQGGLRLLQ DIKETFNRCE EVQLQPPEVW SPDPCQPHSH DFLTDAIVRK MSRMFCQAAR VDLTLDPDTA HPALMLSPDR RGVRLAERRQ EVADHPKRFS ADCCVLGAQG FRSGRHYWEV EVGGRRGWAV GAARESTHHK EKVGPGGSSV GSGDASSSRH HHRRRRLHLP QQPLLQREVW CVGTNGKRYQ AQSSTEQTLL SPSEKPRRFG VYLDYEAGRL GFYNAETLAH VHTFSAAFLG ERVFPFFRVL SKGTRIKLCP
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分子量
71.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIM41 (Tripartite Motif Containing 41) is a member of the TRIM protein family, which plays crucial roles in various cellular processes, including immune response, apoptosis, and development. Research has shown that TRIM41 functions as an E3 ubiquitin ligase, regulating protein stability and modulating signaling pathways involved in inflammation and tumorigenesis. Recent studies have highlighted its potential role in cancer biology, particularly in the context of breast cancer and other malignancies, suggesting that TRIM41 may influence tumor progression and metastasis through its ubiquitination activity. Moreover, TRIM41's involvement in the regulation of autophagy and its interaction with viral proteins indicate its significance in host-pathogen interactions, making it a target of interest for therapeutic strategies. Understanding the structural and functional characteristics of TRIM41 through recombinant protein studies can provide insights into its mechanisms of action and therapeutic potential, paving the way for the development of novel treatments for diseases linked to TRIM41 dysregulation. With advances in protein engineering and purification techniques, generating recombinant TRIM41 can facilitate detailed studies of its biological functions and interactions with other cellular components, ultimately contributing to the broader understanding of its role in health and disease.
