Analytical Data
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Gene name
TRAF7
- Application
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Alternative Names
E3 ubiquitin Protein ligase TRAF7; E3 ubiquitin-Protein ligase TRAF7; RFWD1; Ring finger and WD repeat domain 1; RING finger and WD repeat-containing Protein 1; RING finger Protein 119; RNF119; TNF receptor associated factor 7; TNF receptor-associated factor 7; TRAF7; TRAF7_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6Q0C0
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Expression Region
1-670 aa
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AA Sequence
MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT STYKQHCRTP SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEEEEPEPLV FAEQPSVKLC CQLCCSVFKD PVITTCGHTF CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ IGELFIHCRH GCRVAGSGKP PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP PLLRMNLEAH LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED LMEFRRDASM LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW CLCVYSMGDL LFSGSSDKTI KVWDTCTTYK CQKTLEGHDG IVLALCIQGC KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN PVCTLVSSHN VLFSGSLKAI KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT IKIWDIRTLD CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA VSRGRLFSGA VDSTVKVWTC
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Molecular Weight
74.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRAF7 (TNF Receptor-Associated Factor 7) is a member of the TRAF family, which plays a critical role in mediating signal transduction pathways for various receptors involved in immunity and inflammation. Research has increasingly focused on TRAF7 due to its implicated role in several cellular processes, including apoptosis, cell proliferation, and differentiation. Recent studies have highlighted its involvement in tumorigenesis, particularly in specific cancers where mutations in TRAF7 have been found to contribute to altered signaling pathways that promote oncogenesis. As a result, TRAF7 has emerged as a potential biomarker for cancer prognosis and a target for therapeutic intervention. The recombination of TRAF7 protein allows for the exploration of its structural and functional characteristics, facilitating the study of its interactions with other signaling molecules. Understanding the mechanistic roles of TRAF7 in these pathways not only enhances the comprehension of its biological significance but also opens avenues for developing novel strategies for cancer treatment and other diseases characterized by dysregulated TRAF7 activity. Researchers are investigating recombinant TRAF7 to dissect its function at a molecular level, assess its interaction with specific ligands, and evaluate its impact on cellular responses, which could ultimately contribute to the development of targeted therapies leveraging its unique properties.
