Analytical Data
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基因名
PNMA2
- Application
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别名
PNMA2；KIAA0883；MA2；Paraneoplastic antigen Ma2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UL42
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表达区间
2-361aa
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氨基酸序列
ALALLEDWCRIMSVDEQKSLMVTGIPADFEEAEIQEVLQETLKSLGRYRL LGKIFRKQENANAVLLELLEDTDVSAIPSEVQGKGGVWKVIFKTPNQDTE FLERLNLFLEKEGQTVSGMFRALGQEGVSPATVPCISPELLAHLLGQAMA HAPQPLLPMRYRKLRVFSGSAVPAPEEESFEVWLEQATEIVKEWPVTEAE KKRWLAESLRGPALDLMHIVQADNPSISVEECLEAFKQVFGSLESRRTAQ VRYLKTYQEEGEKVSAYVLRLETLLRRAVEKRAIPRRIADQVRLEQVMAG ATLNQMLWCRLRELKDQGPPPSFLELMKVIREEEEEEASFENESIEEPEE RDGYGRWNHE
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分子量
57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNMA2 (Paraneoplastic Ma Antigen 2) is a protein associated with certain neurodegenerative diseases and paraneoplastic syndromes, particularly in the context of small cell lung cancer. Research into PNMA2 has gained traction due to its role in immune responses and potential involvement in the pathogenesis of neurological disorders. It has been identified as an onconeural antigen, which can elicit an autoimmune response in patients, leading to neurological symptoms. The study of PNMA2 is critical not only for understanding the molecular mechanisms underlying these diseases but also for developing potential diagnostic tools and therapeutic strategies. Recent advances in molecular biology and immunology have facilitated the characterization of PNMA2, including its structure, function, and interaction with other cellular components. By utilizing techniques such as recombinant protein expression and relevant antibody generation, researchers aim to elucidate the precise role of PNMA2 in disease development and progression. The exploration of PNMA2's functional implications may uncover new insights into targeted therapies for patients suffering from paraneoplastic neurological conditions and enhance our understanding of autoimmune responses in cancer-associated syndromes. Overall, the investigation of PNMA2 represents a promising avenue in the intersection of cancer research and neuroimmunology, with the potential for significant clinical impact.
