Analytical Data
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基因名
TP53RK
- Application
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别名
TP53RK; C20orf64; PRPKEKC/KEOPS complex subunit TP53RK; EC 3.6.-.-; Atypical serine/threonine Protein kinase TP53RK; Nori-2; TP53-regulating kinase; EC 2.7.11.1; p53-related Protein kinase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96S44
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表达区间
1-253 aa
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氨基酸序列
MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD EVRLRGRKRS MVG
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分子量
28.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TP53RK (Tumor Protein 53 Response Kinase) is a recently identified protein that plays a crucial role in the cellular response to stress and DNA damage, particularly in the context of cancer biology. Research indicates that TP53RK may influence the functions of the well-known tumor suppressor protein p53, thereby modulating pathways involved in cell cycle regulation, apoptosis, and senescence. Given the pivotal role of p53 in preventing tumor development, understanding TP53RK's mechanisms could unveil new therapeutic targets for cancer treatment. Studies on TP53RK have also highlighted its potential implications in various disease states beyond cancer, including neurodegenerative disorders and metabolic diseases, owing to its involvement in stress response pathways. Consequently, the recombinant expression of TP53RK and its functional characterization are critical for elucidating its biological roles and contributions to tumorigenesis and other diseases. The development of recombinant TP53RK proteins can facilitate detailed biochemical analyses, providing insights into its interactions with other cellular proteins and elucidating its potential as a biomarker or therapeutic target. This makes TP53RK a significant focus of ongoing research aimed at enhancing our understanding of cellular stress responses and the molecular pathways involved in disease progression.
