Analytical Data
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Gene name
TP53RK
- Application
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Alternative Names
TP53RK; C20orf64; PRPKEKC/KEOPS complex subunit TP53RK; EC 3.6.-.-; Atypical serine/threonine Protein kinase TP53RK; Nori-2; TP53-regulating kinase; EC 2.7.11.1; p53-related Protein kinase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96S44
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Expression Region
1-253 aa
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AA Sequence
MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD EVRLRGRKRS MVG
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Molecular Weight
28.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TP53RK (Tumor Protein 53 Response Kinase) is a recently identified protein that plays a crucial role in the cellular response to stress and DNA damage, particularly in the context of cancer biology. Research indicates that TP53RK may influence the functions of the well-known tumor suppressor protein p53, thereby modulating pathways involved in cell cycle regulation, apoptosis, and senescence. Given the pivotal role of p53 in preventing tumor development, understanding TP53RK's mechanisms could unveil new therapeutic targets for cancer treatment. Studies on TP53RK have also highlighted its potential implications in various disease states beyond cancer, including neurodegenerative disorders and metabolic diseases, owing to its involvement in stress response pathways. Consequently, the recombinant expression of TP53RK and its functional characterization are critical for elucidating its biological roles and contributions to tumorigenesis and other diseases. The development of recombinant TP53RK proteins can facilitate detailed biochemical analyses, providing insights into its interactions with other cellular proteins and elucidating its potential as a biomarker or therapeutic target. This makes TP53RK a significant focus of ongoing research aimed at enhancing our understanding of cellular stress responses and the molecular pathways involved in disease progression.
