Analytical Data
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Gene name
THUMPD1
- Application
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Alternative Names
DKFZp686C1054; FLJ20274; THUM1_HUMAN; THUMP domain containing 1; THUMP domain containing Protein 1; THUMP domain-containing Protein 1; THUMPD 1; THUMPD1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXG2
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Expression Region
2-353 aa
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AA Sequence
AAPAQQTTQ PGGGKRKGKA QYVLAKRARR CDAGGPRQLE PGLQGILITC NMNERKCVEE AYSLLNEYGD DMYGPEKFTD KDQQPSGSEG EDDDAEAALK KEVGDIKAST EMRLRRFQSV ESGANNVVFI RTLGIEPEKL VHHILQDMYK TKKKKTRVIL RMLPISGTCK AFLEDMKKYA ETFLEPWFKA PNKGTFQIVY KSRNNSHVNR EEVIRELAGI VCTLNSENKV DLTNPQYTVV VEIIKAVCCL SVVKDYMLFR KYNLQEVVKS PKDPSQLNSK QGNGKEAKLE SADKSDQNNT AEGKNNQQVP ENTEELGQTK PTSNPQVVNE GGAKPELASQ ATEGSKSNEN DFS
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Molecular Weight
39.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THUMPD1, a protein encoded by the THUMPD1 gene, plays a crucial role in various cellular processes, including RNA metabolism and stress responses. Research on THUMPD1 has gained momentum due to its potential implications in diseases, particularly cancer and neurodegenerative disorders. The protein is known to interact with multiple RNA binding proteins and cellular pathways, suggesting a regulatory function in gene expression and cellular homeostasis. Additionally, THUMPD1 has been implicated in the modulation of the cellular stress response, influencing cell survival and differentiation under adverse conditions. Increasing evidence points to its involvement in tumor progression, making it a potential target for therapeutic interventions. However, despite its importance, the detailed mechanisms by which THUMPD1 exerts its functional roles remain largely unexplored. Understanding the structure and function of THUMPD1, particularly through the study of its recombinant forms, could provide valuable insights into its biological relevance and therapeutic potential. This underscores the necessity for further investigation into the biochemical properties and interactions of THUMPD1, as well as its role in disease contexts, paving the way for future research directions aimed at elucidating its function and therapeutic applicability.
