Analytical Data
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基因名
PROC
- Application
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别名
PROC；Vitamin K-dependent Protein C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04070
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表达区间
43-461aa
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氨基酸序列
ANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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分子量
54.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PROC, or protein C, is a vitamin K-dependent plasma protein that plays a crucial role in the regulation of coagulation and the maintenance of hemostatic balance. Its biochemical function primarily involves the inactivation of factors Va and VIIIa, which are essential for the amplification of thrombin generation and clot formation. The study of PROC and its recombinant forms has gained significant traction due to their therapeutic potential in treating disorders related to coagulation, particularly in patients with deficiencies of natural anticoagulants leading to increased thrombotic risks. The production of recombinant PROC (rPROC) offers a promising approach to providing a stable and effective treatment option, potentially circumventing issues such as supply limitations from human plasma. Advances in biotechnology have enabled the development of more efficient expression systems for rPROC, allowing for enhanced yield and functional activity. Additionally, understanding the structure-function relationship of PROC has important implications for designing novel anticoagulant therapies. Recent research has also focused on the role of PROC in inflammation and cell signaling, broadening the scope of its clinical application. As thrombotic diseases remain a major global health issue, ongoing studies into PROC's mechanistic pathways and therapeutic applications continue to be vital in the landscape of coagulation research.
