Analytical Data
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基因名
NID2
- Application
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别名
NID2；Nidogen-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14112
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表达区间
1-969aa
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氨基酸序列
MEGDRVAGRPVLSSLPVLLLLQLLMLRAAALHPDELFPHGESWGDQLLQE GDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFP TDFPAIAPFLADIDTSHGRGRVLYRVNGKVSGHLHVGHTPVHFTDVDLHA YIVGNDGRAYTAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFS LAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQGQVPYVP ANFTAHISPYKELYHYSDSTVTSTSSRDYSLTFGAINQTWSYRIHQNITY QVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSD PTPVNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECA TGFHRCGPNSVCINLPGSYRCECRSAYEFADDRHTCILITPPANPCEDGS HTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAAT CYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGA RFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCG PSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHG KSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSV GTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMV YWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIE TSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGT GRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQ RSHLYGITAVYPYCPTGRK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NID2, or Nidogen-2, is an extracellular matrix (ECM) protein that plays a critical role in tissue architecture and cell-matrix interactions. It is primarily involved in the assembly and stabilization of basement membranes, a specialized type of ECM that underpins various cellular layers in tissues. Research into NID2 has gained significance due to its implications in various physiological processes and pathologies, including cancer metastasis, tissue repair, and fibrosis. Studies show that NID2 interacts with other key ECM components, such as laminins and collagen, influencing cellular behaviors such as adhesion, migration, and differentiation. Moreover, altered levels of NID2 expression have been linked to several diseases, highlighting its potential as a biomarker and therapeutic target. Recent advances in recombinant protein technology have facilitated the study of NID2 by enabling the production of functional recombinant NID2 protein. These studies aim to elucidate its structural properties, molecular interactions, and biological functions in a controlled environment. Understanding the role of NID2 could provide insights into its therapeutic potential in diseases characterized by ECM remodeling, offering new avenues for intervention and treatment strategies. Overall, the research on NID2 recombinant proteins is a promising field that bridges basic biology and clinical applications, seeking to unravel the complexities of ECM dynamics in health and disease.
