Analytical Data
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基因名
RPH3AL
- Application
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别名
RPH3AL；NOC2；Rab effector Noc2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UNE2
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表达区间
1-315aa
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氨基酸序列
MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQRAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWKESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRAPAADAAPAGPSSCLG
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分子量
50.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPH3AL, a member of the RPH (Rabphilin) family, is a protein implicated in the regulation of vesicular transport and synaptic function. Research into RPH3AL has gained momentum due to its involvement in crucial cellular processes such as exocytosis, endocytosis, and synaptic plasticity, all of which are fundamental for neuronal communication and overall brain function. Studies suggest that RPH3AL interacts with GTP-bound Rab proteins, facilitating the docking and fusion of vesicles with target membranes. Dysregulation of RPH3AL has been associated with various neurological disorders, making it a potential biomarker and therapeutic target. Understanding the molecular mechanisms underlying RPH3AL function can shed light on synaptic transmission and its implications in diseases such as Alzheimer's and schizophrenia. The ongoing exploration of RPH3AL, including its structure, binding partners, and role in signaling pathways, offers significant insights into neuronal dynamics and could lead to innovative strategies for intervention in synaptic dysfunctions.
