Cat: PA2000-3502

Recombinant Human RPH3AL Protein,His

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Analytical Data

  • Gene name

    RPH3AL

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    RPH3AL;NOC2;Rab effector Noc2

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9UNE2

  • Expression Region

    1-315aa

  • AA Sequence

    MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQRAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPLPTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWKESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRAPAADAAPAGPSSCLG

  • Molecular Weight

    50.5 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

RPH3AL, a member of the RPH (Rabphilin) family, is a protein implicated in the regulation of vesicular transport and synaptic function. Research into RPH3AL has gained momentum due to its involvement in crucial cellular processes such as exocytosis, endocytosis, and synaptic plasticity, all of which are fundamental for neuronal communication and overall brain function. Studies suggest that RPH3AL interacts with GTP-bound Rab proteins, facilitating the docking and fusion of vesicles with target membranes. Dysregulation of RPH3AL has been associated with various neurological disorders, making it a potential biomarker and therapeutic target. Understanding the molecular mechanisms underlying RPH3AL function can shed light on synaptic transmission and its implications in diseases such as Alzheimer's and schizophrenia. The ongoing exploration of RPH3AL, including its structure, binding partners, and role in signaling pathways, offers significant insights into neuronal dynamics and could lead to innovative strategies for intervention in synaptic dysfunctions.

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