Analytical Data
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基因名
XPG
- Application
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别名
XPG；ERCM2；XPG；XPGC；DNA excision repair Protein ERCC-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28715
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表达区间
947-1186aa
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氨基酸序列
SFLWGKPDLDKIREFCQRYFGWNRTKTDESLFPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVTCMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEESSSLKRKRLSDSKGKNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKNGGATTSSSSDSDDDGGKEKMVLVTARSVFGKKRRKLRRARGRKRKT
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分子量
30.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
XPG, or xeroderma pigmentosum group G, is a key enzyme involved in the nucleotide excision repair (NER) pathway, which is essential for repairing DNA damage caused by ultraviolet (UV) light and other environmental factors. Mutations in the XPG gene can lead to xeroderma pigmentosum, a rare genetic disorder characterized by extreme sensitivity to UV radiation, resulting in a high risk of skin cancer and other severe skin abnormalities. Research on recombinant XPG proteins is critical for understanding the molecular mechanisms of DNA repair and the role of XPG in cellular responses to DNA damage. By producing and studying recombinant XPG, scientists aim to elucidate its structural and functional properties, mechanisms of action, and interactions with other proteins involved in the NER pathway. This research not only enhances our comprehension of the molecular basis of xeroderma pigmentosum but also has broader implications for cancer biology, as defective DNA repair is a hallmark of many cancers. The insights gained from studying recombinant XPG may lead to novel therapeutic strategies for individuals with DNA repair deficiencies and could inform approaches for enhancing the effectiveness of cancer treatments that exploit DNA damage.
