Analytical Data
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Gene name
SMARCE1
- Application
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Alternative Names
BAF57; BRG1 associated factor 57; BRG1-associated factor 57; Chromatin remodeling complex BRG1 associated factor 57; FLJ35648; SMARCE 1; SMARCE1; SMCE1_HUMAN; SWI/SNF related matrix associated actin dependent regulator of chromatin e1; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969G3
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Expression Region
1-411 aa
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AA Sequence
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNPD LKLWEIGKII GGMWRDLTDE EKQEYLNEYE AEKIEYNESM KAYHNSPAYL AYINAKSRAE LEEESRQR QSRMEKGEPY MSIQPAEDPD DYDDGFSMKH TATARFQRNH RLISEILSES VVPDVRSVVT TARMQVLKRQ VQSLMVHQRK LEAELLQIEE RHQEKKRKFL ESTDSFNNEL KRLCGLKVEV DMEKIEIA QAEEQARKRQ EEREKEEQ AERSQSSIVP EEEQNKGE EKKDDENIPM ETEETHLEET TESQQNGEEG TSTPEDKESG QEGVDSMAEE GTSDSNTGSE SNSATVEEPP TDPIPEDEKK E
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Molecular Weight
46.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SMARCE1, also known as the "SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily E, member 1," is a crucial component of the SWI/SNF chromatin remodeling complex, which plays a significant role in regulating gene expression, cell differentiation, and development. The protein is involved in modifying chromatin structure, thereby influencing DNA accessibility for transcription factors and other regulatory proteins. Research has demonstrated that mutations or dysregulation of SMARCE1 are linked to several human diseases, including cancer and developmental disorders. Given its pivotal role in chromatin dynamics, the study of SMARCE1 reconstituted proteins offers valuable insight into the mechanisms of chromatin remodeling and its impact on gene regulation. Recombination and detailed characterization of SMARCE1 can aid in understanding its structural and functional properties, facilitating the exploration of potential therapeutic targets for diseases associated with its dysfunction. The synthesis of SMARCE1 recombinant protein enables researchers to investigate its interactions with other chromatin-associated proteins and to determine its biochemical properties in vitro. This research not only enhances our comprehension of chromatin biology but also unveils the potential for innovative approaches in the treatment of disorders linked to SMARCE1 aberrations, making it a significant focus in the fields of molecular biology and therapeutics.
