Analytical Data
-
Gene name
SLC37A4
- Application
-
Alternative Names
G6PT1; G6PT1_HUMAN; G6PT2; G6PT3; Glucose-5-phosphate transporter; Glucose-6-phosphatase; transport (glucose) protein 3; Glucose-6-phosphatase; transport (glucose-6-phosphate) protein 1; Glucose-6-phosphatase; transport (phosphate/pyrophosphate) protein 2.; Glucose-6-phosphate translocase; Glucose-6-phosphate transporter 1; GSD1b; GSD1c; GSD1d; MGC15729; Microsomal glucose-6-phosphate transporter; PRO0685; SLC37A4; Solute carrier family 37 (glucose-6-phosphate transporter); member 4; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19; TRG19
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
O43826
-
Expression Region
1-429 aa
-
AA Sequence
MAAQGYGYYRTVIFSAMFGGYSLYYFNRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSARWLFSSGLLLVGLVNIFFAWSSTVPVFAALWFLNGLAQGLGWPPCGKVLRKWFEPSQFGTWWAILSTSMNLAGGLGPILATILAQSYSWRSTLALSGALCVVVSFLCLLLIHNEPADVGLRNLDPMPSEGKKGSLKEESTLQELLLSPYLWVLSTGYLVVFGVKTCCTDWGQFFLIQEKGQSALVGSSYMSALEVGGLVGSIAAGYLSDRAMAKAGLSNYGNPRHGLLLFMMAGMTVSMYLFRVTVTSDSPKLWILVLGAVFGFSSYGPIALFGVIANESAPPNLCGTSHAIVGLMANVGGFLAGLPFSTIAKHYSWSTAFWVAEVICAASTAAFFLLRNIRTKMGRVSKKAE
-
Molecular Weight
72.8 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC37A4, a member of the solute carrier family, encodes a protein involved in the transport of glucose-6-phosphate and phosphate across cellular membranes. This protein plays a crucial role in the metabolic processes of various tissues, including the liver, brain, and skeletal muscles. Mutations in the SLC37A4 gene lead to a condition known as glycogen storage disease type IIB (GSD-IIB), characterized by recurrent hypoglycemic episodes and excessive glycogen accumulation in lysosomes. Research on SLC37A4 recombinant proteins is vital for understanding its physiological functions and the pathophysiology of GSD-IIB. By producing and characterizing these recombinant proteins, scientists aim to elucidate the transport mechanisms of glucose-6-phosphate and other related substrates, paving the way for potential therapeutic strategies. Additionally, studying SLC37A4 may provide insights into the design of enzyme replacement therapies and novel treatment approaches for metabolic disorders linked to impaired glucose homeostasis. Understanding the structure and function of SLC37A4 recombinant proteins could also aid in identifying potential biomarkers for early diagnosis and personalized treatment protocols for patients affected by GSD-IIB and related metabolic diseases. Therefore, ongoing research in this field is essential to improving our knowledge of SLC37A4 and its implications in human health.
