Analytical Data
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Gene name
ABCA12
- Application
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Alternative Names
ABCA12；ABC12；Glucosylceramide transporter ABCA12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86UK0
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCA12 is a member of the ATP-binding cassette (ABC) transporter family, playing a critical role in lipid transport and homeostasis within lipid-rich tissues such as the skin. Mutations in the ABCA12 gene are associated with a variety of Ichthyosis disorders, particularly harlequin ichthyosis, a severe skin condition. The protein itself is involved in the transport of ceramides and other lipids necessary for maintaining the skin barrier function. Due to its significant role in human health, ABCA12 has become a focal point of research aiming to understand its functional mechanisms, the biochemical pathways it affects, and its implications in dermatological diseases. Recent studies have focused on characterizing recombinant ABCA12 proteins to elucidate their transport capabilities, structural properties, and interactions with various lipid substrates. By developing recombinant forms of ABCA12, researchers aim to investigate how mutations affect its function, thereby advancing our understanding of related skin disorders and potential therapeutic approaches. This research is essential not only for developing targeted treatments for conditions arising from ABCA12 dysfunction but also for broader insights into lipid metabolism and cellular transport mechanisms.
