Analytical Data
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基因名
ABCA12
- Application
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别名
ABCA12；ABC12；Glucosylceramide transporter ABCA12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86UK0
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCA12 is a member of the ATP-binding cassette (ABC) transporter family, playing a critical role in lipid transport and homeostasis within lipid-rich tissues such as the skin. Mutations in the ABCA12 gene are associated with a variety of Ichthyosis disorders, particularly harlequin ichthyosis, a severe skin condition. The protein itself is involved in the transport of ceramides and other lipids necessary for maintaining the skin barrier function. Due to its significant role in human health, ABCA12 has become a focal point of research aiming to understand its functional mechanisms, the biochemical pathways it affects, and its implications in dermatological diseases. Recent studies have focused on characterizing recombinant ABCA12 proteins to elucidate their transport capabilities, structural properties, and interactions with various lipid substrates. By developing recombinant forms of ABCA12, researchers aim to investigate how mutations affect its function, thereby advancing our understanding of related skin disorders and potential therapeutic approaches. This research is essential not only for developing targeted treatments for conditions arising from ABCA12 dysfunction but also for broader insights into lipid metabolism and cellular transport mechanisms.
