Analytical Data
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基因名
SLC2A8
- Application
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别名
SLC2A8; GLUT8; GLUTX1; Solute carrier family 2; facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NY64
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表达区间
1-477 aa
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氨基酸序列
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
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分子量
77.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC2A8, also known as GLUT8, is a member of the glucose transporter family that plays a crucial role in the transport of glucose and other hexoses across cellular membranes. Its expression is primarily observed in various tissues, including the brain and testes, indicating its potential significance in neurological function and spermatogenesis. Recent studies have highlighted the association of SLC2A8 with insulin sensitivity and metabolic disorders, making it a potential target for therapeutic intervention in conditions like obesity and diabetes. Additionally, SLC2A8's involvement in the transport of other substrates, such as fructose and inositol, suggests that it may also play a role in cellular signaling and metabolism beyond mere glucose transport. To better understand the functional characteristics of SLC2A8 and its implications in health and disease, researchers have focused on the production and analysis of recombinant SLC2A8 proteins. This involves the cloning of the SLC2A8 gene into expression vectors, followed by the expression of the protein in suitable host systems. The purified recombinant protein can then be utilized for various biochemical studies, including substrate specificity assays, kinetic analysis, and structural studies, which are essential for elucidating the molecular mechanisms underlying its transport functions. Overall, the investigation of SLC2A8 through recombinant protein technology is vital for advancing our understanding of its biological roles and therapeutic potential in various metabolic disorders.
