Analytical Data
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基因名
SLC2A4
- Application
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别名
insulin-responsive; Glucose transporter GLUT 4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; Insulin responsive glucose transporter type 4; kug; SLC 2A4; SLC2A4; solute carrier family 2 (facilitated glucose transporter) member 4; Solute carrier family 2 member 4; Solute carrier family 2. facilitated glucose transporter member 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P14672
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表达区间
1-509 aa
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氨基酸序列
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
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分子量
81.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC2A4, also known as GLUT4 (Glucose Transporter Type 4), is a critical protein involved in glucose metabolism and insulin signaling. It primarily functions in adipose tissue and skeletal muscle, facilitating glucose uptake in response to insulin stimulation. Dysregulation of GLUT4 is associated with metabolic disorders, including type 2 diabetes and obesity. Research on SLC2A4 recombinant protein is essential for understanding its molecular mechanisms and physiological roles. The study of GLUT4's structure and function can provide insights into its interactions with insulin and other signaling molecules, potentially leading to therapeutic strategies for enhancing glucose homeostasis in metabolic diseases. Furthermore, expressing and purifying SLC2A4 as a recombinant protein allows researchers to investigate its biochemical properties, such as substrate affinity and transporter kinetics, in a controlled environment. This research is crucial for developing drugs that can effectively target GLUT4, thus offering new avenues for treating insulin resistance and related conditions. Additionally, as scientists explore the mechanisms of GLUT4 translocation to the plasma membrane, it becomes evident that understanding its behavior under various physiological and pathological states can pave the way for innovative treatments aimed at improving glucose uptake and overall metabolic health.
