Analytical Data
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基因名
RASSF5
- Application
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别名
RASSF5；NORE1；RAPL；Ras association domain-containing Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WWW0
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表达区间
1-265aa
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氨基酸序列
MTVDSSMSSGYCSLDEELEDCFFTAKTTFFRNAQSKHLSKNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
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分子量
57.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human SCARA3 Protein，His
Cat：PA1000-7657
Recombinant Human SCARA5 Protein，His
Cat：PA1000-7656
Protein Description
RASSF5, part of the RASSF (Ras Association Domain Family) gene family, is a key regulator in various cellular processes, including cell cycle progression, apoptosis, and tumor suppression. As a scaffolding protein, RASSF5 interacts with numerous signaling pathways, particularly those mediated by the Ras and Hippo pathways, which are crucial for maintaining cellular homeostasis and regulating cell growth. Research has indicated that RASSF5 plays a significant role in inhibiting tumorigenesis; loss of its expression has been linked to several types of cancer, including lung, breast, and colorectal cancers. Additionally, RASSF5 has been suggested to modulate cellular responses to stress and can influence the stability of other tumor suppressor proteins, further underscoring its importance in cancer biology. Understanding the functional mechanisms and pathways associated with RASSF5 can provide insights into its potential as a therapeutic target and contribute to the development of novel cancer treatments. Consequently, the study of recombinant RASSF5 protein is pivotal in dissecting its biological roles, interactions, and the implications of its dysregulation in cancer progression. This research not only enhances our understanding of RASSF5's involvement in tumor suppression but also paves the way for exploring its utility in clinical applications and biomarker development for cancer diagnosis and prognosis.
