Analytical Data
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基因名
SLC25A11
- Application
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别名
SLC25A11; SLC20A4; Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; Solute carrier family 25 member 11
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02978
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表达区间
1-314 aa
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氨基酸序列
MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG
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分子量
60.28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC25A11, part of the solute carrier family, encodes a mitochondrial transporter responsible for the exchange of aspartate and glutamate across the inner mitochondrial membrane. This protein plays a crucial role in cellular metabolism, particularly in amino acid metabolism and energy production. Dysregulation or mutations in SLC25A11 have been linked to various metabolic disorders and neurodegenerative diseases, highlighting its importance in cellular function and health. Research into SLC25A11 recombinant proteins has gained traction as scientists aim to elucidate its structural and functional characteristics, allowing for a better understanding of its role in mitochondrial dynamics and neurotransmitter regulation. The production of recombinant SLC25A11 provides a valuable tool for in vitro studies, enabling the analysis of transporter activity, substrate specificity, and the impact of potential pharmacological agents. With advances in protein engineering and expression systems, detailed investigations of SLC25A11 can pave the way for therapeutic interventions targeting mitochondrial dysfunction associated with several diseases. Further studies will not only enhance our understanding of the metabolism and physiology mediated by SLC25A11 but also open avenues for potential drug development aimed at restoring normal transporter function in pathological conditions. This research is vital for deciphering the complexities of mitochondrial metabolism and its implications for overall cellular health and disease mechanisms.
