Analytical Data
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Gene name
FETUB
- Application
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Alternative Names
FETUB；Fetuin-B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UGM5
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Expression Region
16-382aa
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AA Sequence
CGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLN RVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYG QCKAIFYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNH QVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESP CTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATG SENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNS QEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPKEKART AECPGPAQNASPLVLPP
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Molecular Weight
42 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FETUB, the FETU-binding protein, is a crucial protein involved in iron metabolism and transport within the human body. Research into FETUB has gained significance due to its potential implications in various physiological and pathological conditions, particularly those related to iron homeostasis. Alterations in FETUB expression have been associated with disorders such as hemochromatosis, anemia, and other iron overload diseases. As a binding partner for transferrin and other iron-regulating factors, FETUB plays a vital role in modulating cellular iron levels, influencing both systemic and local iron distribution. Investigations into the structure and function of FETUB can illuminate its regulatory mechanisms and interactions, providing insights into how iron balance is maintained at the cellular level. Given that iron is essential for numerous biological processes but can be toxic in excess, understanding FETUB's role may pave the way for novel therapeutic strategies targeting iron-related disorders. The recombinant production of FETUB facilitates detailed studies on its biochemical properties, interactions, and potential impacts on iron metabolism, furthering our understanding and opening new avenues for clinical applications in managing diseases associated with dysregulated iron homeostasis.
