Analytical Data
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Gene name
SETD6
- Application
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Alternative Names
SETD6; N-lysine methyltransferase SETD6; EC 2.1.1.-; SET domain-containing protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TBK2
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Expression Region
1-473 aa
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AA Sequence
MATQAKRPRV AGPVDGGDLD PVACFLSWCR RVGLELSPKV SERAGGRRTR GGARAALTSP PAQVAVSRQG TVAGYGMVAR ESVQAGELLF VVPRAALLSQ HTCSIGGLLE RERVALQSQS GWVPLLLALL HELQAPASRW RPYFALWPEL GRLEHPMFWP EEERRCLLQG TGVPEAVEKD LANIRSEYQS IVLPFMEAHP DLFSLRVRSL ELYHQLVALV MAYSFQEPLE EEEDEKEPNS PVMVPAADIL NHLANHNANL EYSANCLRMV ATQPIPKGHE IFNTYGQMAN WQLIHMYGFV EPYPDNTDDT ADIQMVTVRE AALQGTKTEA ERHLVYERWD FLCKLEMVGE EGAFVIGREE VLTEEELTTT LKVLCMPAEE FRELKDQDGG GDDKREEGSL TITNIPKLKA SWRQLLQNSV LLTLQTYATD LKTDQGLLSN KEVYAKLSWR EQQALQVRYG QKMILHQLLE LTS
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Molecular Weight
53.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SETD6 (SET Domain Containing 6) is a member of the SET domain family of proteins, which are known for their role as histone methyltransferases. Research has shown that SETD6 is involved in the regulation of gene expression through its ability to modify histones and other substrates, specifically by catalyzing the mono-methylation of histone H3 at lysine 4 (H3K4me1). This modification is crucial for various biological processes, including transcriptional activation and chromatin remodeling. Recent studies have linked SETD6 to several cellular processes, including differentiation, development, and response to environmental stimuli. Additionally, SETD6 has been implicated in the progression of various diseases, including cancer, where its dysregulation may contribute to altered gene expression profiles. Understanding the function of SETD6 and its interactions with other proteins and regulatory pathways is essential for elucidating its role in health and disease. The development of recombinant SETD6 proteins for biochemical and structural studies is a critical step in advancing our knowledge of this protein's functional mechanisms and potential therapeutic applications. These studies could provide insights into targeted therapies for diseases associated with SETD6 dysregulation, emphasizing the need for continued research in this area. Overall, SETD6 represents a promising target for future investigations into epigenetic regulation and disease treatment strategies.
