Analytical Data
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Gene name
SEC61A2
- Application
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Alternative Names
SEC61A2; Protein transport protein Sec61 subunit alpha isoform 2; Sec61 alpha-2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H9S3
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Expression Region
1-476 aa
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AA Sequence
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
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Molecular Weight
78.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC61A2 is a key component of the Sec61 translocon complex, which plays a crucial role in the translocation of proteins across the endoplasmic reticulum (ER) membrane. This protein facilitates the proper folding and maturation of nascent polypeptides as they enter the ER, influencing a wide array of cellular processes, including secretion and membrane biogenesis. Recent studies have highlighted the significance of SEC61A2 in various physiological and pathological contexts, including its involvement in the immune response and potential links to diseases such as cancer and neurodegenerative disorders. Recombinant SEC61A2 proteins are of great interest for biochemical and structural studies, enabling researchers to dissect the molecular mechanisms governing protein translocation and membrane interactions. Furthermore, understanding the functional dynamics of SEC61A2 can provide insights into the therapeutic targeting of the translocon complex in diseases characterized by dysregulated protein synthesis or misfolding. The continuous exploration of SEC61A2's role in cellular physiology and its potential as a drug target underscores the importance of this protein in both basic research and clinical applications, making it a focal point of current biochemistry and molecular biology investigations.
