Analytical Data
-
基因名
CHD1
- Application
-
别名
ATP dependent helicase CHD 1; ATP-dependent helicase CHD1; CHD 1; CHD-1; Chd1; CHD1_HUMAN; Chromodomain helicase DNA binding Protein 1
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O14646
-
表达区间
1177 -1272 a.a
-
氨基酸序列
IKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGS
-
分子量
36.3 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CHD1 (Chromodomain Helicase DNA-binding protein 1) is a member of the CHD family of ATP-dependent chromatin remodelers, which play crucial roles in various cellular processes, including DNA replication, repair, and transcription regulation. Recent studies have implicated CHD1 in the maintenance of genome integrity and the epigenetic regulation of gene expression, highlighting its importance in development and cellular differentiation. Mutations and dysregulation of CHD1 have been associated with various cancers and genetic disorders, making it a potential therapeutic target. The recombinant study of CHD1 focuses on understanding its structural and functional properties, enabling researchers to explore its interaction with DNA and histones, as well as its role in chromatin dynamics. By producing CHD1 as a recombinant protein, researchers can investigate its enzymatic activity and binding properties in detail, which is essential for elucidating its mechanisms of action in chromatin remodeling. This research not only enhances our understanding of CHD1's biological functions but also paves the way for potential applications in cancer therapy and regenerative medicine, where restoring normal chromatin dynamics may mitigate disease progression. As such, recombination studies of CHD1 represent a significant endeavor in the field of molecular biology and cancer research, aimed at bridging the gap between basic science and clinical applications.
