Analytical Data
-
Gene name
SCMH1
- Application
-
Alternative Names
Polycomb protein SCMH1; SCMH 1; SCMH1; SCMH1_HUMAN; Scml 3; Scml3; Sex comb on midleg 1; Sex comb on midleg homolog 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q96GD3
-
Expression Region
1-660 aa
-
AA Sequence
MLVCYSVLAC EILWDLPCSI MGSPLGHFTW DKYLKETCSV PAPVHCFKQS YTPPSNEFKI SMKLEAQDPR NTTSTCIATV VGLTGARLRL RLDGSDNKND FWRLVDSAEI QPIGNCEKNG GMLQPPLGFR LNASSWPMFL LKTLNGAEMA PIRIFHKEPP SPSHNFFKMG MKLEAVDRKN PHFICPATIG EVRGSEVLVT FDGWRGAFDY WCRFDSRDIF PVGWCSLTGD NLQPPGTKVV IPKNPYPASD VNTEKPSIHS STKTVLEHQP GQRGRKPGKK RGRTPKTLIS HPISAPSKTA EPLKFPKKRG PKPGSKRKPR TLLNPPPASP TTSTPEPDTS TVPQDAATIP SSAMQAPTVC IYLNKNGSTG PHLDKKKVQQ LPDHFGPARA SVVLQQAVQA CIDCAYHQKT VFSFLKQGHG GEVISAVFDR EQHTLNLPAV NSITYVLRFL EKLCHNLRSD NLFGNQPFTQ THLSLTAIEY SHSHDRYLPG ETFVLGNSLA RSLEPHSDSM DSASNPTNLV STSQRHRPLL SSCGLPPSTA SAVRRLCSRG VLKGSNERRD MESFWKLNRS PGSDRYLESR DASRLSGRDP SSWTVEDVMQ FVREADPQLG PHADLFRKHE IDGKALLLLR SDMMMKYMGL KLGPALKLSY HIDRLKQGKF
-
Molecular Weight
73.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SCMH1 (S-phase cyclin A-associated protein) is a protein that plays a crucial role in cell cycle regulation and has gained significant attention in research due to its involvement in various cellular processes, including DNA repair, cell proliferation, and apoptosis. It is a member of the SCM (Skp1-Cullin-F-box) family of proteins, which are known to function as ubiquitin ligases that regulate protein degradation and turnover. Previous studies have indicated that SCMH1 can interact with cyclins and other cell cycle-related proteins, highlighting its potential impact on cell cycle progression and its relevance in cancer biology. Dysregulation of SCMH1 expression has been associated with several malignancies, suggesting that it could serve as a potential biomarker for cancer diagnosis or prognosis. Moreover, its role in modulating the activity of key signaling pathways further emphasizes the importance of understanding SCMH1's function in cellular contexts. As research into SCMH1 continues to evolve, the exploration of its molecular mechanisms and the development of recombinant SCMH1 protein are crucial for elucidating its biological significance, paving the way for potential therapeutic applications in cancer treatment and other diseases characterized by cell cycle dysregulation.
