Analytical Data
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Gene name
LILRB1
- Application
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Alternative Names
LILRB1；HLA-6.0；HLAG；HLA class I histocompatibility antigen. alpha chain G
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NHL6
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Expression Region
24-458aa
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AA Sequence
GHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRLYREKKTAPWITRI PQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTGAYI KPTLSAQPSPVVNSGGNVTLQCDSQVAFDGFILCKEGEDEHPQCLNSQPH ARGSSRAIFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVS KKPSLSVQPGPIVAPEETLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQP QAGLSQANFTLGPVSRSYGGQYRCYGAHNLSSEWSAPSDPLDILIAGQFY DRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKEGAADDPWRLRSTY QSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVSGPS GGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRH
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LILRB1, or Leukocyte Immunoglobulin-Like Receptor B1, is a crucial receptor expressed on various immune cells, including monocytes, dendritic cells, and T cells. It plays a significant role in immune regulation by modulating the activation and inhibition of immune responses. The research on LILRB1 has gained momentum due to its involvement in various pathological conditions, including cancer, autoimmune diseases, and infections. The receptor is known to bind to MHC class I molecules, which allows it to participate in the immune evasion mechanisms employed by tumors. The study of LILRB1 recombinant protein is vital for understanding its structural features and interactions with ligands, providing insights into its physiological functions and mechanisms of action. Additionally, the characterization of LILRB1 as a therapeutic target has opened new avenues for the development of treatments that can manipulate immune responses to enhance anti-tumor immunity or restore immune balance in autoimmunity. Vaccines and monoclonal antibodies targeting LILRB1 may also be explored as potential strategies to improve the efficacy of existing therapies. Consequently, the recombinant production of LILRB1 facilitates high-throughput screening and functional assays, making it an essential tool in both basic research and clinical applications concerning immune modulation.
