Analytical Data
-
Gene name
VEGFR2
- Application
-
Alternative Names
VEGFR2；FLK1；VEGFR2；Vascular endothelial growth factor receptor 2
-
Species
Mouse
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P35918
-
Expression Region
20-762aa
-
AA Sequence
ASVGLPGDFLHPPKLSTQKDILTILANTTLQITCRGQRDLDWLWPNAQRDSEERVLVTECGGGDSIFCKTLTIPRVVGNDTGAYKCSYRDVDIASTVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLNVSLCARYPEKRFVPDGNRISWDSEIGFTLPSYMISYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSAGEKLVLNCTARTELNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVTKSDQGEYTCVASSGRMIKRNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLIILERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLE
-
Molecular Weight
110 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Vascular endothelial growth factor receptor 2 (VEGFR2) is a crucial receptor that plays a significant role in angiogenesis, vascular permeability, and endothelial cell functions. It is primarily activated by its ligands, vascular endothelial growth factors (VEGFs), which are essential for both normal physiological processes and pathological conditions such as cancer, ischemic diseases, and inflammatory disorders. Given its pivotal role in promoting blood vessel formation and maintenance, VEGFR2 has emerged as a promising target for therapeutic interventions aimed at inhibiting excessive angiogenesis. Researchers have been developing recombinant VEGFR2 proteins to study their structure, function, and interactions with VEGFs and various inhibitors. These studies facilitate a better understanding of the signaling pathways involved in angiogenesis and help identify potential drug candidates for treating angiogenesis-related diseases. Moreover, recombinant VEGFR2 proteins serve as valuable tools in drug screening assays and biomarker development, contributing to the advancement of personalized medicine approaches. The exploration of VEGFR2 also extends to its involvement in tumor microenvironments, where its expression can influence cancer progression and metastasis. As such, the ongoing research on VEGFR2 recombinant proteins holds great promise for uncovering novel therapeutic strategies and enhancing our understanding of vascular biology and disease mechanisms.
