Analytical Data
-
Gene name
TMOD4
- Application
-
Alternative Names
TMOD4；Tropomodulin-4
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9NZQ9
-
Expression Region
1-345aa
-
AA Sequence
MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPTGPLDREALLQYLEQQALEVKERDDLVPFTGEKKGKPYIQPKREIPAEEQITLEPELEEALAHATDAEMCDIAAILDMYTLMSNKQYYDALCSGEICNTEGISSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMKANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENATLTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQQKKR
-
Molecular Weight
66.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMOD4, or tropomodulin 4, is a member of the tropomodulin family, which plays a crucial role in regulating actin filament dynamics and stabilization in muscle and non-muscle cells. Research into TMOD4 has gained importance due to its potential involvement in various cellular processes, including muscle development, cell motility, and the maintenance of cellular shape. Unlike other tropomodulin isoforms, TMOD4 is predominantly expressed in the heart and brain, indicating its specialized functions in these tissues. Recent studies have focused on the structural and functional characterization of recombinant TMOD4 proteins, exploring their interactions with actin filaments and other cytoskeletal components. This research not only aids in understanding the molecular mechanics of TMOD4 but also opens avenues for exploring its implications in cardiac and neurological disorders. By generating and analyzing TMOD4 recombinant proteins, researchers aim to elucidate its regulatory mechanisms and potential as a therapeutic target in diseases associated with abnormal actin dynamics. Understanding TMOD4's role in the actin cytoskeleton is pivotal for advancing our knowledge of cellular architecture and function, as well as for the development of novel treatment strategies for conditions linked to actin filament anomalies.
