Analytical Data
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Gene name
RNF151
- Application
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Alternative Names
RNF151; RING finger protein 151
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2KHN1
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Expression Region
1-245 aa
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AA Sequence
MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR QKTCPCCRKE VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK GHQDSCPFEL TACPNEGCTS QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL DPAERARHNC YRELHNAWSV RQERRRPLLL SLLRRVRWLD QATSVVRREL AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA NIPCK
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Molecular Weight
27.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF151 (RING finger protein 151) is an E3 ubiquitin ligase that plays a crucial role in regulating various cellular processes, including cell cycle progression, DNA damage response, and apoptosis. The importance of RNF151 in these pathways has drawn significant attention from researchers, particularly in understanding its implications in cancer biology and neurodegenerative diseases. Studies have shown that RNF151 is involved in the ubiquitylation of target proteins, marking them for degradation and thus influencing protein homeostasis within the cell. This regulation is essential for maintaining cellular functions and responses to stress. Moreover, dysregulation of RNF151 expression or activity has been linked to tumorigenesis, making it a potential biomarker for cancer progression and a novel therapeutic target. Recent research focuses on the structure-function relationship of RNF151, seeking to elucidate its molecular mechanisms and substrate interaction. By developing recombinant RNF151 proteins, scientists aim to perform in vitro assays to explore its catalytic activity and identify potential small-molecule inhibitors that could modulate its function. Overall, the study of RNF151 not only enhances our understanding of ubiquitin-mediated signaling pathways but also opens new avenues for therapeutic interventions in diseases characterized by cell cycle and apoptotic deregulation.
