Analytical Data
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基因名
RICS
- Application
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别名
ARHGAP32; GRIT; KIAA0712; RICS; Rho GTPase-activating protein 32; Brain-specific Rho GTPase-activating protein; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GTPase regulator interacting with TrkA; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling; p200RhoGAP; p250GAP
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
A7KAX9
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表达区间
1-322 aa
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氨基酸序列
MPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLLPHFSARTELIVPFPLRLLRKQFTPPLLGPMSPLNPLVQITVCISI
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分子量
61.16 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The RICS (Regulator of G-protein Signaling) protein family plays a crucial role in various cellular processes, particularly those involving signal transduction. Research into RICS proteins has gained momentum due to their significant involvement in regulating G-protein signaling pathways, which are essential for numerous physiological functions including cell proliferation, differentiation, and migration. Abnormalities in G-protein signaling can lead to a wide range of diseases, including cancer and cardiovascular disorders. Thus, understanding the structural and functional properties of RICS proteins is vital for developing therapeutic strategies. Recent advancements in structural biology, such as X-ray crystallography and cryo-electron microscopy, have facilitated detailed studies on the conformational dynamics and interactions of RICS proteins, providing insights into their regulatory mechanisms. Furthermore, ongoing studies are focusing on post-translational modifications and their effects on RICS activity, which could unveil new regulatory layers in G-protein signaling. Overall, the investigation of RICS proteins stands at the intersection of biochemistry, molecular biology, and pharmacology, paving the way for innovative treatments targeting dysregulated signaling pathways.
