Analytical Data
-
Gene name
C9orf100
- Application
-
Alternative Names
ARG39_HUMAN; Arhgef39; C9orf100; Chromosome 9 open reading frame 100; FLJ14642; Hypothetical Protein LOC84904; MGC44886; Rho guanine nucleotide exchange factor (GEF) 39; Rho guanine nucleotide exchange factor 39; RP11 331F9.7; RP11-331F9.7; Vav like Protein C9orf100
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8N4T4
-
Expression Region
1-335aa
-
AA Sequence
MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKN
-
Molecular Weight
62.59 KDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C9orf100, a protein encoded by the gene located on chromosome 9, has garnered attention in recent years due to its potential implications in neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Studies have suggested that mutations or abnormal expressions of C9orf100 may play a crucial role in the pathogenesis of these conditions. The exact function of C9orf100 remains largely unclear, but it is thought to be involved in cellular stress responses and neuroinflammation, processes that are commonly disrupted in neurodegenerative disorders. Researchers have increasingly focused on characterizing the recombinant C9orf100 protein to investigate its biological properties and interactions with other cellular components. This includes assessing its role in neuronal health and function, as well as its potential as a biomarker for early diagnosis. Understanding the molecular mechanisms by which C9orf100 contributes to disease progression could pave the way for novel therapeutic strategies aimed at targeting its pathways. The ongoing research into C9orf100, therefore, not only enhances our comprehension of its fundamental biological roles but also holds promise for unlocking new avenues in the treatment of ALS and FTD, which have significant social and health implications given their progressive nature and the limited treatment options currently available.
