Analytical Data
-
基因名
RASGRP2
- Application
-
别名
Calcium and DAG-regulated; Calcium and DAG-regulated guanine nucleotide exchange factor I; Calcium-and diacylglycerol-regulated guanine nucleotide exchange factor I; CalDAG-GEFI; Cdc25 like protein; Cdc25-like protein; F25B3.3 kinase like protein; F25B3.3 kinase-like protein; GRP2_HUMAN; HCDC25L; RAS guanyl releasing protein 2; RAS guanyl-releasing protein 2; Rasgrp2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q7LDG7
-
表达区间
1-609 aa
-
氨基酸序列
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY QQSRKDNSNS LQVKTCHLVR YWISAFPAEF DLNPELAEQI KELKALLDQE GNRRHSSLID IDSVPTYKWK RQVTQRNPVG QKKRKMSLLF DHLEPMELAE HLTYLEYRSF CKILFQDYHS FVTHGCTVDN PVLERFISLF NSVSQWVQLM ILSKPTAPQR ALVITHFVHV AEKLLQLQNF NTLMAVVGGL SHSSISRLKE THSHVSPETI KLWEGLTELV TATGNYGNYR RRLAACVGFR FPILGVHLKD LVALQLALPD WLDPARTRLN GAKMKQLFSI LEELAMVTSL RPPVQANPDL LSLLTVSLDQ YQTEDELYQL SLQREPRSKS SPTSPTSCTP PPRPPVLEEW TSAAKPKLDQ ALVVEHIEKM VESVFRNFDV DGDGHISQEE FQIIRGNFPY LSAFGDLDQN QDGCISREEM VSYFLRSSSV LGGRMGFVHN FQESNSLRPV ACRHCKALIL GIYKQGLKCR ACGVNCHKQC KDRLSVECRR RAQSVSLEGS APSPSPMHSH HHRAFSFSLP RPGRRGSRPP EIREEEVQTV EDGVFDIHL
-
分子量
69.2 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RASGRP2 is a member of the Ras guanine nucleotide exchange factor family, which plays a pivotal role in the regulation of RAS signaling pathways. These pathways are critical for various cellular processes, including cell proliferation, differentiation, and survival. RASGRP2 is particularly involved in hematopoietic cells, where it contributes to platelet activation and function. Research has indicated that dysregulation of RASGRP2 may lead to several hematological disorders, including thrombosis and certain cancers. The study of RASGRP2 recombinant protein is significant for enhancing our understanding of its biological functions and the underlying mechanisms of diseases associated with its dysfunction. By producing and characterizing this protein, researchers aim to explore its interaction with other molecules in signaling pathways, its role in platelet signaling, and its potential as a therapeutic target. Additionally, understanding how RASGRP2 regulates its downstream effects could provide insight into developing innovative strategies for treating related disorders, particularly in the context of abnormal platelet activity or malignancies. Overall, research focused on RASGRP2 not only expands our knowledge of cell signaling dynamics but also paves the way for targeted therapeutic interventions in hematological diseases.
