Analytical Data
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基因名
RASAL3
- Application
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别名
RASAL3; RAS protein activator like-3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86YV0
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表达区间
1-264 aa
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氨基酸序列
MRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT
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分子量
56.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASAL3, a member of the RAS GTPase-activating protein (GAP) family, plays a crucial role in the regulation of RAS signaling pathways, which are pivotal for various cellular functions, including proliferation, differentiation, and survival. Dysregulation of RAS signaling is often implicated in cancer and other diseases, making RASAL3 a significant focus for therapeutic research. Initial studies have shown that RASAL3 can negatively regulate RAS activity, thus serving as a potential tumor suppressor. Its expression levels are altered in certain cancers, suggesting a relationship between its function and tumorigenesis. Researchers have been investigating the structural and functional properties of RASAL3, including the identification of specific domains responsible for its GAP activity and the mechanisms by which it interacts with RAS and other cellular partners. Understanding the molecular mechanisms underlying RASAL3 function could provide insights into its role in cancer progression and open new avenues for targeted therapies. Furthermore, as RASAL3 may also have implications in neurological disorders and immune responses, its comprehensive study could advance our understanding of its multifaceted roles in human health and disease.
