Analytical Data
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基因名
HLA-A
- Application
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别名
HLA-A；HLAA；HLA class I histocompatibility antigen. A alpha chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30443
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表达区间
25-308aa
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氨基酸序列
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPI
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分子量
38.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HLA-A recombinant proteins have emerged as a focal point in immunological research due to their crucial role in the human immune response. Human leukocyte antigen (HLA) class I molecules, including HLA-A, are integral for presenting peptide fragments to CD8+ T cells, facilitating the detection and elimination of infected or malignant cells. Understanding the structure and function of HLA-A is essential for developing targeted immunotherapies and vaccines, as variations in HLA-A expression can influence individual immune responses and susceptibility to diseases. Furthermore, the study of HLA-A recombinants has significant implications for organ transplantation, as mismatches can lead to graft rejection. Advances in recombinant DNA technology enable researchers to produce HLA-A proteins in vitro, allowing for detailed analysis of their binding affinities, polymorphism, and interactions with T cell receptors. Such studies not only enhance our knowledge of T cell activation mechanisms but also aid in identifying potential biomarkers for diseases and improving personalized medicine approaches. The continued exploration of HLA-A recombinant proteins positions them as vital tools in advancing therapeutic strategies for autoimmune diseases, cancers, and transplantation medicine.
