Analytical Data
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基因名
RAD9A
- Application
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别名
Cell cycle checkpoint control protein; Cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD 9; hRAD9; Rad 9; RAD 9A; RAD9 (S pombe) homolog ; RAD9 homolog A; RAD9 homolog; Rad9a; RAD9A_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99638
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表达区间
1-391 aa
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氨基酸序列
MKCLVTGGNV KVLGKAVHSL SRIGDELYLE PLEDGLSLRT VNSSRSAYAC FLFAPLFFQQ YQAATPGQDL LRCKILMKSF LSVFRSLAML EKTVEKCCIS LNGRSSRLVV QLHCKFGVRK THNLSFQDCE SLQAVFDPAS CPHMLRAPAR VLGEAVLPFS PALAEVTLGI GRGRRVILRS YHEEEADSTA KAMVTEMCLG EEDFQQLQAQ EGVAITFCLK EFRGLLSFAE SANLNLSIHF DAPGRPAIFT IKDSLLDGHF VLATLSDTDS HSQDLGSPER HQPVPQLQAH STPHPDDFAN DDIDSYMIAM ETTIGNEGSR VLPSISLSPG PQPPKSPGPH SEEEDEAEPS TVPGTPPPKK FRSLFFGSIL APVRSPQGPS PVLAEDSEGE G
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分子量
42.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAD9A is an essential protein involved in the DNA damage response and repair mechanisms, playing a critical role in maintaining genomic stability. This protein is part of the 9-1-1 complex, which is activated in response to DNA damage and is crucial for cell cycle checkpoint activation and the facilitation of repair processes. Given its involvement in tumorigenesis, RAD9A has gained attention as a potential biomarker for cancer progression and a target for therapeutic intervention. Studies have indicated that overexpression of RAD9A is linked to various cancers, suggesting its role as a promoter of cancer cell proliferation and survival. Additionally, RAD9A interacts with several key regulatory proteins, influencing pathways related to apoptosis and DNA repair, making it a pivotal player in cellular responses to genotoxic stress. Hence, the study of RAD9A and its recombinant forms is crucial for understanding its precise biological functions, interactions, and potential applications in cancer therapy. Researchers aim to elucidate the molecular mechanisms underlying RAD9A's involvement in the DNA damage response, which may lead to novel strategies in cancer treatment and prevention. By generating recombinant RAD9A proteins, scientists can investigate their biochemical properties and interactions, aiding in the development of targeted therapies that exploit the vulnerabilities associated with its dysregulation in cancer cells.
