Analytical Data
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基因名
GRN
- Application
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别名
GRN；Progranulin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P28799
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表达区间
18-593aa
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氨基酸序列
TRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHC SAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSG NNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPH GAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPD GSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENAT TDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCED HIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCD NVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ RGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACC QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVK DVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAA RGTKCLRREAPRWDAPLRDPALRQLL
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分子量
63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRN (Glycogen Synthase Kinase-3 Regulating Protein) is a crucial component in cellular signaling pathways, particularly in the regulation of various physiological processes such as neuronal development, immune responses, and cell metabolism. Research on GRN recombinant proteins has gained significant attention due to their potential implications in understanding disease mechanisms and developing targeted therapies. The GRN gene, known for its role in neurodegenerative disorders like frontotemporal dementia, has prompted investigations into how alterations in its expression and function can lead to pathological conditions. Advances in recombinant DNA technology have facilitated the production of GRN proteins, allowing researchers to study their structure-function relationships and interactions with other cellular components. This line of research is pivotal for uncovering novel therapeutic targets and strategies aimed at modulating GRN activity, thereby providing insights into potential treatments for diseases associated with GRN dysregulation. By harnessing the power of recombinant protein technology, scientists are striving to elucidate the multifaceted roles of GRN in health and disease, paving the way for innovative biomedical applications.
