Analytical Data
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基因名
PTCD2
- Application
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别名
Pentatricopeptide repeat domain 2; Pentatricopeptide repeat-containing protein 2; Pentatricopeptide repeat-containing protein 2 mitochondrial; Ptcd2; PTCD2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WV60
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表达区间
1-388 aa
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氨基酸序列
MVRDSMAAAF RPSNRVLLQA LQILVYPGVG GSGSVSCRCP LGAKRYLLTD NVVKLKEFQQ KKVAVACNLS GTKETYFRNL KKKLTQNKLI LKGELITLLH LCESRDHVEL AKNVIYRYHA ENKNFTLGEY KFGPLFVRLC YELDLEESAV ELMKDQHLRG FFSDSTSFNI LMDMLFIKGK YKSALQVLIE MKNQDVKFTK DTYVLAFAIC YKLNSPESFK ICTTLREEAL LKGEILSRRA SCFAVALALN QNEMAKAVSI FSQIMNPESI ACINLNIIIH IQSNMLENLI KTLKNAAEGN LSKFVKRHVF SEEVLAKVRE KVKDVPALVA KFDEIYGTLH ITGQVTTDSL DAVLCHTPRD RKSHTLLLNK RMVSRRTFQP LSQSLLAE
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分子量
43.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTCD2, or Pentatricopeptide repeat-containing protein 2, is a crucial protein involved in post-transcriptional regulation of mitochondrial gene expression. Recent studies have highlighted its role in mitochondrial function, as it is implicated in the editing and regulation of mitochondrial RNA, which is vital for proper mitochondrial protein synthesis. Mitochondria are the powerhouses of the cell, and any dysfunction in their genetic regulation can lead to a variety of metabolic disorders and mitochondrial diseases. Understanding PTCD2's structure and function is essential for elucidating the mechanisms of mitochondrial gene expression and its implications in health and disease. The recombinant expression of PTCD2 allows researchers to investigate its biochemical properties, interaction with RNA, and potential as a therapeutic target. Additionally, studying PTCD2 can enhance our understanding of the molecular pathways involved in mitochondrial biogenesis and dynamics, which are critical for maintaining cellular energy homeostasis. With mitochondria being central to numerous physiological processes, insights gained from PTCD2 research may pave the way for novel strategies in treating mitochondrial-related diseases, making it a significant focus in contemporary molecular biology and therapeutic development.
