Analytical Data
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Gene name
PSIP1
- Application
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Alternative Names
PSIP1；DFS70；LEDGF；PSIP2；PC4 and SFRS1-interacting Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75475
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Expression Region
1-530aa
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AA Sequence
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
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Molecular Weight
76.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSIP1, also known as the PC4 and SFRS1-interacting protein 1, is a crucial factor implicated in various cellular processes, including gene expression regulation, DNA repair, and cell cycle control. Its role as an adaptor protein in the transcriptional co-activation machinery highlights its importance in facilitating the interaction between transcription factors and the RNA polymerase II complex. Studies have shown that PSIP1 participates in the cellular response to DNA damage, thereby influencing mechanisms of genomic stability and tumorigenesis. The protein is encoded by the PSIP1 gene located on chromosome 11 and has distinct functional domains that mediate its interactions with other proteins, including HIV-1 integrase, suggesting a significant role in viral replication and pathogenesis. Research into PSIP1 has expanded due to its potential implications in cancer biology, as alterations or dysregulation of its function may contribute to oncogenic processes. Furthermore, its involvement in pathways related to alternative splicing and gene regulation positions PSIP1 as a promising target for therapeutic interventions. Consequently, characterizing PSIP1 and understanding its molecular mechanisms offers valuable insights not only into fundamental biological functions but also into the development of novel strategies for managing cancer and viral infections. Ongoing studies aim to elucidate the structural properties of PSIP1, its interaction networks, and the consequences of its biochemical activity on cellular homeostasis, making it a vital subject of research in molecular biology and oncology.
