Analytical Data
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基因名
PSIP1
- Application
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别名
PSIP1；DFS70；LEDGF；PSIP2；PC4 and SFRS1-interacting Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75475
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表达区间
1-530aa
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氨基酸序列
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
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分子量
76.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSIP1, also known as the PC4 and SFRS1-interacting protein 1, is a crucial factor implicated in various cellular processes, including gene expression regulation, DNA repair, and cell cycle control. Its role as an adaptor protein in the transcriptional co-activation machinery highlights its importance in facilitating the interaction between transcription factors and the RNA polymerase II complex. Studies have shown that PSIP1 participates in the cellular response to DNA damage, thereby influencing mechanisms of genomic stability and tumorigenesis. The protein is encoded by the PSIP1 gene located on chromosome 11 and has distinct functional domains that mediate its interactions with other proteins, including HIV-1 integrase, suggesting a significant role in viral replication and pathogenesis. Research into PSIP1 has expanded due to its potential implications in cancer biology, as alterations or dysregulation of its function may contribute to oncogenic processes. Furthermore, its involvement in pathways related to alternative splicing and gene regulation positions PSIP1 as a promising target for therapeutic interventions. Consequently, characterizing PSIP1 and understanding its molecular mechanisms offers valuable insights not only into fundamental biological functions but also into the development of novel strategies for managing cancer and viral infections. Ongoing studies aim to elucidate the structural properties of PSIP1, its interaction networks, and the consequences of its biochemical activity on cellular homeostasis, making it a vital subject of research in molecular biology and oncology.
