Analytical Data
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基因名
OLR1
- Application
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别名
OLR1；CLEC8A；LOX1；Oxidized low-density lipoProtein receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78380
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表达区间
58-273aa
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氨基酸序列
MQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ
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分子量
28.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OLR1 (Oxidized Low-Density Lipoprotein Receptor 1) is a scavenger receptor primarily involved in the endocytosis of oxidized low-density lipoproteins (oxLDL), playing a crucial role in lipid metabolism and atherosclerosis. Its expression is upregulated in various inflammatory conditions and cardiovascular diseases, highlighting its significant role in cellular response to oxidative stress and inflammation. Research on recombinant OLR1 proteins is driven by the need to better understand its structure-function relationship, signaling pathways, and potential as a therapeutic target. By producing OLR1 as a recombinant protein, scientists can study its interactions with oxLDL and other ligands, elucidate its role in cellular processes such as foam cell formation, and explore its involvement in disease mechanisms. Additionally, recombinant OLR1 is valuable for developing diagnostic tools and therapeutic interventions aimed at cardiovascular diseases. Understanding the nuances of OLR1's function may lead to innovative strategies for modulating its activity and mitigating the effects of atherosclerosis and related disorders. Through these investigations, researchers aim to pave the way for novel therapeutic avenues that could significantly impact cardiovascular health and disease management.
