Analytical Data
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Gene name
OLR1
- Application
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Alternative Names
OLR1；CLEC8A；LOX1；Oxidized low-density lipoProtein receptor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P78380
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Expression Region
58-273aa
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AA Sequence
MQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ
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Molecular Weight
28.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OLR1 (Oxidized Low-Density Lipoprotein Receptor 1) is a scavenger receptor primarily involved in the endocytosis of oxidized low-density lipoproteins (oxLDL), playing a crucial role in lipid metabolism and atherosclerosis. Its expression is upregulated in various inflammatory conditions and cardiovascular diseases, highlighting its significant role in cellular response to oxidative stress and inflammation. Research on recombinant OLR1 proteins is driven by the need to better understand its structure-function relationship, signaling pathways, and potential as a therapeutic target. By producing OLR1 as a recombinant protein, scientists can study its interactions with oxLDL and other ligands, elucidate its role in cellular processes such as foam cell formation, and explore its involvement in disease mechanisms. Additionally, recombinant OLR1 is valuable for developing diagnostic tools and therapeutic interventions aimed at cardiovascular diseases. Understanding the nuances of OLR1's function may lead to innovative strategies for modulating its activity and mitigating the effects of atherosclerosis and related disorders. Through these investigations, researchers aim to pave the way for novel therapeutic avenues that could significantly impact cardiovascular health and disease management.
