Analytical Data
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Gene name
IRF7
- Application
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Alternative Names
IRF7；Interferon regulatory factor 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92985
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Expression Region
1-503aa
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AA Sequence
MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIFKAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHKVYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSLCLSSANSLYDDIECFLMELEQPA
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Molecular Weight
60.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IRF7 (Interferon Regulatory Factor 7) is a pivotal transcription factor in the innate immune response, primarily responsible for the regulation of type I interferon (IFN) production in response to viral infections. It is activated by various signaling pathways following the recognition of pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRRs). Research into IRF7 has gained momentum due to its critical role in orchestrating the antiviral immune response and its potential implications in autoimmune diseases and cancer. The ability of IRF7 to induce the expression of genes involved in the antiviral response makes it a significant focus for therapeutic interventions aimed at enhancing host defense against viral pathogens. Moreover, understanding its regulatory mechanisms can provide insights into the pathogenesis of various diseases characterized by dysregulated immune responses. The development of recombinant IRF7 protein has facilitated the study of its functional properties, interactions with other signaling molecules, and downstream effects on gene expression. By elucidating the structure-function relationship of IRF7, researchers aim to uncover novel strategies to modulate its activity for improved antiviral therapies and to harness its potential in vaccine development. Thus, the study of IRF7 not only enhances our comprehension of innate immunity but also holds promise for translational applications in clinical settings.
