Analytical Data
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基因名
KLKB1
- Application
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别名
KLKB1；KLK3；Plasma kallikrein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P03952
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表达区间
20-390aa
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氨基酸序列
GCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTR
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分子量
43.4kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLKB1, the gene encoding the plasma kallikrein protein, plays a crucial role in the kallikrein-kinin system, which is involved in various physiological processes including blood pressure regulation, inflammation, and pain. Dysregulation of KLKB1 has been implicated in several cardiovascular and inflammatory diseases, making it a significant target for therapeutic intervention. Research into KLKB1 recombinant proteins focuses on understanding its structure-function relationship and elucidating its role in physiological and pathological states. Recombinant KLKB1 can be produced in various expression systems, allowing for the analysis of its biochemical properties, enzymatic activity, and interactions with other proteins. This research is vital for developing novel treatments for conditions associated with KLKB1 dysregulation, such as hereditary angioedema and other thrombotic disorders. Moreover, studying KLKB1 recombinant protein offers insights into its potential roles in cancer progression and autoimmune diseases, positioning it as a promising candidate for drug development and biomarker discovery. Advances in recombinant DNA technology have enabled the generation of KLKB1 protein variants, which can be used to investigate the effects of specific mutations and post-translational modifications on its activity. This research not only enhances our understanding of KLKB1's biological functions but also opens avenues for innovative therapeutic strategies targeting the kallikrein-kinin system. In summary, KLKB1 recombinant protein research is a dynamic field aimed at unraveling complex biological interactions and developing novel clinical applications.
