Analytical Data
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基因名
SMARCC1
- Application
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别名
SMARCC1；BAF155；SWI/SNF complex subunit SMARCC1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92922
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表达区间
451-671aa
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氨基酸序列
IPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGLVPLHLRSPQVPAAQQMLNFPEKNKEKPVDLQNFGLRTDIYSKKTLAKSKGASAGREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYL
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分子量
41.5kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SMARCC1, a key component of the SWI/SNF chromatin remodeling complex, plays a pivotal role in regulating gene expression and maintaining chromatin structure. Dysregulation of SMARCC1 has been implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. Research has shown that SMARCC1 interacts with numerous transcription factors and co-regulators to modulate the accessibility of chromatin, thereby influencing cellular processes such as differentiation, proliferation, and response to environmental cues. Additionally, studies have highlighted its involvement in DNA repair mechanisms, suggesting that alterations in its function may contribute to genomic instability. As researchers continue to explore the functional dynamics of SMARCC1, including its post-translational modifications and interactions with other molecular pathways, it stands out as a critical focus for understanding the intricate network of gene regulation and its implications for health and disease. The development of recombinant SMARCC1 protein enables detailed studies of its structure-function relationships, offering insights into its mechanistic roles and potential as a biomarker or therapeutic target in oncology and other fields.
