Analytical Data
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基因名
PLEKHN1
- Application
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别名
PLEKHN1; CLPABP; Pleckstrin homology domain-containing family N member 1; PH domain-containing family N member 1; Cardiolipin and phosphatidic acid-binding protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q494U1
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表达区间
1-663 aa
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氨基酸序列
MGNSHCVPQA PRRLRASFSR KPSLKGNRED SARMSAGLPG PEAARSGDAA ANKLFHYIPG TDILDLENQR ENLEQPFLSV FKKGRRRVPV RNLGKVVHYA KVQLRFQHSQ DVSDCYLELF PAHLYFQAHG SEGLTFQGLL PLTELSVCPL EGSREHAFQI TGVWDASRAP RGTPDPGLGE GPALWLRSTC VYVCALSALP AGPLPAPLLV LCPSRAELDR WLYHLEKQTA LLGGPRRCHS APPQGSCGDE LPWTLQRRLT RLRTASGHEP GGSAVCASRV KLQHLPAQEQ WDRLLVLYPT SLAIFSEELD GLCFKGELPL RAVHINLEEK EKQIRSFLIE GPLINTIRVV CASYEDYGHW LLCLRAVTHR EGAPPLPGAE SFPGSQVMGS GRGSLSSGGQ TSWDSGCLAP PSTRTSHSLP ESSVPSTVGC SSQHTPDQAN SDRASIGRRR TELRRSGSSR SPGSKARAEG RGPVTPLHLD LTQLHRLSLE SSPDAPDHTS ETSHSPLYAD PYTPPATSHR RVTDVRGLEE FLSAMQSARG PTPSSPLPSV PVSVPASDPR SCSSGPAGPY LLSKKGALQS RAAQRHRGSA KDGGPQPPDA PQLVSSAREG SPEPWLPLTD GRSPRRSRDP GYDHLWDETL SSSHQKCPQL GGPEASGGLV QWI
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分子量
66.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PLEKHN1, a member of the pleckstrin homology (PH) domain-containing family of proteins, has garnered significant interest due to its potential roles in cellular signaling and cytoskeletal dynamics. Research has pointed to PLEKHN1's involvement in various biological processes, including cell adhesion, migration, and differentiation. It is implicated in important signaling pathways, particularly those related to the immune response and neuronal function. Recent studies suggest that PLEKHN1 may act as an adaptor protein that links membrane-bound receptors to cytosolic signaling cascades, thereby influencing cellular responses to external stimuli. Given its significant role in health and disease, particularly in cancer progression and neurodegenerative disorders, the production of recombinant PLEKHN1 protein has become a focus area for researchers. By engineering and purifying this protein, scientists aim to elucidate its structure-function relationships and regulatory mechanisms. Additionally, understanding PLEKHN1's interactions with other cellular components could provide insights into its functional roles in normal physiology and various pathologies. The study of PLEKHN1 is not only pivotal for basic research but also holds potential for therapeutic applications where modulation of its activity could lead to novel treatment strategies.
