Analytical Data
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基因名
BAP1
- Application
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别名
BAP 1; Bap1; BAP1_HUMAN; BRCA 1 associated Protein 1; BRCA1 associated Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92560
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表达区间
1-729aa
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氨基酸序列
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGLS AVRTMEAFHF VSYVPITGRL FELDGLKVYP IDHGPWGEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRIK YEARLHVLKV NRQTVLEALQ QLIRVTQPEL IQTHKSQESQ LPEESKSASN KSPLVLEANR APAASEGNHT DGAEEAAGSC AQAPSHSPPN KPKLVVKPPG SSLNGVHPNP TPIVQRLPAF LDNHNYAKSP MQEEEDLAAG VGRSRVPVRP PQQYSDDEDD YEDDEEDDVQ NTNSALRYKG KGTGKPGALS GSADGQLSVL QPNTINVLAE KLKESQKDLS IPLSIKTSSG AGSPAVAVPT HSQPSPTPSN ESTDTASEIG SAFNSPLRSP IRSANPTRPS SPVTSHISKV LFGEDDSLLR VDCIRYNRAV RDLGPVISTG LLHLAEDGVL SPLALTEGGK GSSPSIRPIQ GSQGSSSPVE KEVVEATDSR EKTGMVRPGE PLSGEKYSPK ELLALLKCVE AEIANYEACL KEEVEKRKKF KIDDQRRTHN YDEFICTFIS MLAQEGMLAN LVEQNISVRR RQGVSIGRLH KQRKPDRRKR SRPYKAKRQ
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分子量
80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
BAP1, or BRCA1-associated protein 1, is a nuclear deubiquitinase that plays a crucial role in the regulation of various cellular processes, including DNA damage response, cell cycle regulation, and apoptosis. It is encoded by the BAP1 gene located on chromosome 3p21.1 and has emerged as a significant player in tumorigenesis, particularly in cancers such as mesothelioma, melanoma, and other malignancies associated with familial cancer syndromes. BAP1 functions through its ability to remove ubiquitin moieties from target proteins, thereby influencing their stability and activity. Mutations or losses of BAP1 expression have been linked to poor prognosis and increased tumor aggressiveness. Research into BAP1 has gained momentum since its discovery as a tumor suppressor gene, with studies aimed at understanding its molecular mechanisms, regulatory networks, and interactions with other signaling pathways. Furthermore, the identification of BAP1 as a potential biomarker for cancer susceptibility has sparked interest in developing targeted therapies. Current investigations focus on elucidating the functional implications of BAP1 alterations and exploring its potential as a therapeutic target, emphasizing the need for comprehensive studies that connect genetic findings with clinical outcomes in cancer patients. As the field evolves, BAP1 continues to represent a promising area of research, with the potential to significantly impact cancer diagnostics and treatment strategies.
