Analytical Data
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Gene name
SLC34A2
- Application
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Alternative Names
SLC34A2；Sodium-dependent phosphate transport Protein 2B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95436-1
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Expression Region
191-362aa
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AA Sequence
GTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDL
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Molecular Weight
20.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC34A2, a member of the solute carrier family, encodes a sodium-dependent phosphate transporter primarily expressed in the kidney and lungs. This protein plays a critical role in phosphate homeostasis, facilitating the reabsorption of inorganic phosphate in renal tubular cells. Dysregulation of SLC34A2 has been implicated in various conditions, including renal phosphate wasting disorders and certain pulmonary diseases. Furthermore, mutations in the SLC34A2 gene are associated with hereditary leiomyomatosis and renal cell cancer, highlighting its significance in both metabolic and oncological contexts. Research on recombinant SLC34A2 protein has been essential for understanding its structure-function relationship, regulatory mechanisms, and interactions with other cellular components. Functional studies using recombinant proteins establish a clear relationship between SLC34A2 activity and phosphate transport efficiency, shedding light on the potential therapeutic targets for conditions related to phosphate dysregulation. Additionally, the production of recombinant SLC34A2 provides valuable tools for investigating its role in disease and for developing novel therapeutic strategies aimed at restoring phosphate balance in affected individuals. The study of this transporter not only enhances our understanding of phosphate metabolism but also offers insights into broader physiological mechanisms and disease processes influenced by this essential nutrient.
