Recombinant Human SLC34A2 Protein，His

SLC34A2, a member of the solute carrier family, encodes a sodium-dependent phosphate transporter primarily expressed in the kidney and lungs. This protein plays a critical role in phosphate homeostasis, facilitating the reabsorption of inorganic phosphate in renal tubular cells. Dysregulation of SLC34A2 has been implicated in various conditions, including renal phosphate wasting disorders and certain pulmonary diseases. Furthermore, mutations in the SLC34A2 gene are associated with hereditary leiomyomatosis and renal cell cancer, highlighting its significance in both metabolic and oncological contexts. Research on recombinant SLC34A2 protein has been essential for understanding its structure-function relationship, regulatory mechanisms, and interactions with other cellular components. Functional studies using recombinant proteins establish a clear relationship between SLC34A2 activity and phosphate transport efficiency, shedding light on the potential therapeutic targets for conditions related to phosphate dysregulation. Additionally, the production of recombinant SLC34A2 provides valuable tools for investigating its role in disease and for developing novel therapeutic strategies aimed at restoring phosphate balance in affected individuals. The study of this transporter not only enhances our understanding of phosphate metabolism but also offers insights into broader physiological mechanisms and disease processes influenced by this essential nutrient.