Analytical Data
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Gene name
PI4KAP2
- Application
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Alternative Names
PI4KAP2; Putative phosphatidylinositol 4-kinase alpha-like protein P2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A4QPH2
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Expression Region
1-592 aa
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AA Sequence
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLLE QLVEENTGSL SGPAKDFYQR EFDFFNKITN VSAIIKPYPK GDERKKACLS ALSEVTVQPG CSLPSNPEAI VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RTPTDRILRL PASQDMLALQ IIDLFKNIFQ LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD FGMYDYFTRQ YGDESTLAFQ QACYNFIRSM AAYSLLLFLL QIKDRHNGNI MLDKKGHIIH IDFGFMFESS PGGNLGWEPD IKLTDEMVMI MGGKMEATPF KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR GQTIKFLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY
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Molecular Weight
66.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PI4KAP2 (Phosphatidylinositol 4-kinase II alpha) is a crucial enzyme involved in the phosphoinositide signaling pathway, which plays a significant role in various cellular processes, including membrane trafficking, cytoskeletal dynamics, and cell signaling. As a member of the phosphatidylinositol 4-kinase family, PI4KAP2 is primarily responsible for phosphorylating phosphatidylinositol to produce phosphatidylinositol 4-phosphate (PI4P), a key lipid molecule that acts as a precursor for further phosphorylation reactions leading to the creation of more complex phosphoinositides. The study of PI4KAP2 and the characterization of its recombinant protein are vital for understanding its physiological functions and mechanisms of action within the cell. Dysregulation of PI4KAP2 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting the importance of this protein in health and disease. By producing and analyzing recombinant PI4KAP2, researchers aim to elucidate its structural and functional properties, explore its interactions with other cellular molecules, and identify potential therapeutic targets for diseases associated with phosphoinositide signaling imbalances. This line of research could provide valuable insights into designing novel treatments or strategies to modulate PI4KAP2 activity, thereby influencing key cellular functions and disease outcomes.
