Analytical Data
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Gene name
VPS29
- Application
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Alternative Names
VPS29；Vacuolar Protein sorting-associated Protein 29
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UBQ0
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Expression Region
1-182aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMMLVLV LGDLHIPHRC NSLPAKFKKL LVPGKIQHIL CTGNLCTKES YDYLKTLAGD VHIVRGDFDE NLNYPEQKVV TVGQFKIGLI HGHQVIPWGD MASLALLQRQ FDVDILISGH THKFEAFEHE NKFYINPGSA TGAYNALETN IIPSFVLMDI QASTVVTYVY QLIGDDVKVE RIEYKKP
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Molecular Weight
23 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VPS29, a protein implicated in the retromer complex, plays a crucial role in intracellular transport and membrane trafficking, particularly in the recycling of proteins from endosomes to the trans-Golgi network. Its involvement in maintaining cellular homeostasis has garnered significant attention due to its potential implications in various diseases, including neurodegenerative disorders and cancer. Research has shown that VPS29 is essential for the proper function of the retromer, which is responsible for the retrieval of specific membrane proteins, thus preventing their degradation and ensuring their availability for cellular functions. Studies have indicated that mutations or dysregulation of VPS29 can lead to mislocalization of cargo proteins, contributing to pathological conditions. Moreover, VPS29 has been associated with crucial pathways, such as those regulating the immune response and cellular signaling. Understanding the structure and function of VPS29 is vital not only for comprehending its role in basic cellular processes but also for exploring its potential as a therapeutic target. The development of recombinant VPS29 proteins allows for detailed biochemical analyses, enabling researchers to investigate its interactions, mechanisms of action, and effects on cellular health. As interest in VPS29 continues to grow, elucidating its functions and the pathways it influences may provide valuable insights into developing novel strategies for treating diseases associated with its dysfunction.
