Analytical Data
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Gene name
VAMP4
- Application
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Alternative Names
VAMP4；Vesicle-associated membrane Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75379
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Expression Region
1-141aa
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AA Sequence
MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES SDNATAFSN RSKQLRRQMW WRGCKIKAIM ALVAAILLLV IIILIVMKYR T
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VAMP4, or Vesicle-Associated Membrane Protein 4, is a member of the VAMP family crucial for the regulation of intracellular membrane trafficking. This protein is primarily associated with the transport of vesicles between the trans-Golgi network and the plasma membrane, playing a significant role in exocytosis and endocytosis processes. Research on VAMP4 has gained momentum due to its potential implications in various physiological and pathological conditions, including neurodegenerative diseases, diabetes, and cancer. Understanding the molecular mechanisms governing VAMP4’s function can provide insights into how membrane dynamics contribute to cellular homeostasis. Moreover, VAMP4's potential as a therapeutic target makes it a focal point for drug development aimed at modulating its activity to restore normal cellular functions impaired in disease states. Recent advancements in recombinant protein technologies have facilitated the expression and purification of VAMP4, enabling detailed biochemical and structural studies. This foundational research is essential for elucidating its role in cellular processes and for the development of innovative therapeutic strategies. As investigations continue to unravel the complexities of VAMP4 and its interactions within cellular environments, its significance in cell biology and medical research becomes increasingly clear, positioning it as a key player in both fundamental research and clinical applications.
