Analytical Data
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Gene name
TUBa1C
- Application
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Alternative Names
TUBa1C；TUBA6；Tubulin alpha-1C chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQE3
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Expression Region
1-449aa
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AA Sequence
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY
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Molecular Weight
49.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TUBa1C, a member of the tubulin protein family, plays a crucial role in microtubule dynamics and cellular structure regulation. As a fundamental component of the cytoskeleton, TUBa1C is involved in various cellular processes such as cell division, intracellular transport, and the maintenance of cell shape. The study of TUBa1C has gained significant attention due to its implications in neurodevelopmental disorders and certain forms of cancer, where alterations in tubulin expression or function can lead to aberrant cellular behavior. Furthermore, TUBa1C serves as a promising target for therapeutic interventions aimed at modulating microtubule dynamics. Recent research focuses on the reconstitution of TUBa1C protein to better understand its structural properties, interactions with other microtubule-associated proteins, and its role in disease mechanisms. By utilizing recombinant DNA technology, researchers can produce TUBa1C in vitro, allowing for detailed biochemical and biophysical analyses. This approach not only elucidates the fundamental biology of TUBa1C but also provides insights into potential drug design aimed at targeting related pathways in diseases. Understanding the functional dynamics of TUBa1C could pave the way for novel strategies in treating disorders associated with microtubule dysregulation, highlighting its importance in both basic and applied biomedical research.
