Analytical Data
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Gene name
ARL13B
- Application
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Alternative Names
ADP ribosylation factor like 13B; ADP ribosylation factor like 2 like 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3SXY8
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Expression Region
1-428aa
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AA Sequence
MFSLMASCCG WFKRWREPVR KVTLLMVGLD NAGKTATAKG IQGEYPEDVA PTVGFSKINL RQGKFEVTIF DLGGGIRIRG IWKNYYAESY GVIFVVDSSD EERMEETKEA MSEMLRHPRI SGKPILVLAN KQDKEGALGE ADVIECLSLE KLVNEHKCLC QIEPCSAISG YGKKIDKSIK KGLYWLLHVI ARDFDALNER IQKETTEQRA LEEQEKQERA ERVRKLREER KQNEQEQAEL DGTSGLAELD PEPTNPFQPI ASVIIENEGK LEREKKNQKM EKDSDGCHLK HKMEHEQIET QGQVNHNGQK NNEFGLVENY KEALTQQLKN EDETDRPSLE SANGKKKTKK LRMKRNHRVE PLNIDDCAPE SPTPPPPPPP VGWGTPKVTR LPKLEPLGET HHNDFYRKPL PPLAVPQRPN SDAHDVIS
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Molecular Weight
48.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARL13B is a member of the ADP-ribosylation factor (ARF) family of small GTPases, primarily known for its role in cilia and flagella function. It is essential in regulating various cellular processes such as cell signaling, trafficking, and cytoskeletal dynamics. Due to its critical involvement in ciliary formation and maintenance, ARL13B has garnered significant attention in research related to ciliopathies, a group of genetic disorders arising from defects in cilia function. Mutations in the ARL13B gene are associated with conditions like Joubert syndrome, which is characterized by neurological and developmental issues. The study of recombinant ARL13B protein provides valuable insights into its biochemical properties, interactions with other cellular proteins, and its regulatory mechanisms in ciliary signaling pathways. Understanding the structure-function relationship of ARL13B can help elucidate the molecular basis of diseases linked to ciliary dysfunction and may pave the way for therapeutic interventions targeting these pathways. Moreover, the recombinant protein can be utilized to explore its potential as a biomarker or therapeutic target in various cilia-related disorders, underscoring its significance in both basic and translational research.
