Analytical Data
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Gene name
PARVB
- Application
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Alternative Names
PARVB; CGI-56; Beta-parvin; Affixin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HBI1
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Expression Region
1-364 aa
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AA Sequence
MSSAPRSPTP RPRRMKKDES FLGKLGGTLA RKRRAREVSD LQEEGKNAIN SPMSPALVDV HPEDTQLEEN EERTMIDPTS KEDPKFKELV KVLLDWINDV LVEERIIVKQ LEEDLYDGQV LQKLLEKLAG CKLNVAEVTQ SEIGQKQKLQ TVLEAVHDLL RPRGWALRWS VDSIHGKNLV AILHLLVSLA MHFRAPIRLP EHVTVQVVVV RKREGLLHSS HISEELTTTT EMMMGRFERD AFDTLFDHAP DKLSVVKKSL ITFVNKHLNK LNLEVTELET QFADGVYLVL LMGLLEDYFV PLHHFYLTPE SFDQKVHNVS FAFELMLDGG LKKPKARPED VVNLDLKSTL RVLYNLFTKY KNVE
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Molecular Weight
41.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The PARVB gene, which encodes the protein Parvin-B, plays a crucial role in various cellular processes, including signal transduction and cell adhesion. It is part of the parvin protein family, which is involved in linking integrins to the actin cytoskeleton and regulating focal adhesion dynamics. Research into PARVB has gained traction due to its implications in various physiological and pathological conditions, such as cancer metastasis and cardiovascular diseases. As a member of the focal adhesion complex, PARVB is essential for maintaining cell structure and transmitting signals that influence cell migration and proliferation. Furthermore, alterations in PARVB expression have been associated with tumor progression, making it a potential biomarker and therapeutic target in cancer treatment. Investigating the biochemical pathways and molecular mechanisms of PARVB can provide valuable insights into its function and the broader implications for cellular behavior in health and disease. Consequently, the development of recombinant PARVB proteins has become a significant area of research, facilitating the functional analysis of this protein and its interactions with other cellular components. Understanding these dynamics at the molecular level could inform future therapeutic strategies aimed at modulating PARVB activity in various disease contexts.
