Analytical Data
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Gene name
PAGE2
- Application
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Alternative Names
PAGE2; GAGEC2; GAGEE2; P antigen family member 2; PAGE-2; G antigen family C 2; Prostate-associated gene 2 protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z2X7
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Expression Region
1-111 aa
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AA Sequence
MSELLRARSQ SSERGNDQES SQPVGSVIVQ EPTEEKRQEE EPPTDNQGIA PSGEIENQAV PAFQGPDMEA FQQELALLKI EDEPGDGPDV REGIMPTFDL TKVLEAGDAQ P
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Molecular Weight
12.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAGE2 (P antigen family member 2) is a cancer/testis (CT) antigen, primarily expressed in testicular germ cells and various tumors, making it a candidate for targeted cancer immunotherapy. Unlike many normal tissues, PAGE2 expression is largely restricted to malignant cells, which positions it as a potential target for therapeutic strategies that exploit the immune system to recognize and attack cancer cells. Recent studies have suggested that PAGE2 plays a role in promoting tumor growth and survival, thus highlighting its significance in oncogenesis. As a member of the PAGE family, PAGE2 shares structural similarities with other CT antigens, known for their immunogenic properties, which may allow for the development of novel vaccines or T-cell therapies aimed at eliciting an immune response against tumors expressing PAGE2. Given that cancer cells can often evade immune detection, understanding the biology of PAGE2, including its expression patterns and immune evasion mechanisms, is crucial for the design of effective immunotherapeutic approaches. Overall, the investigation of PAGE2 not only enhances our understanding of cancer biology but also holds promise for advancing personalized medicine strategies in cancer treatment.
